Porta San Biagio is one of the three gateways to the ancient heart of Lecce, dedicated to Saint Blaise, bishop of the city of Sebaste in Armenia in the 4th century. It constitutes the southern entrance to the old urban core. It is located near Piazza d'Italia.

Built on the site of an older gate commissioned by Charles V, Porta San Biagio was rebuilt in 1774 at the behest of the governor of Terra d'Otranto, Tommaso Ruffo, as evidenced by the Latin inscription placed at the top. The gate, characterized by pairs of smooth-shafted columns resting on high plinths, is surmounted by the coat of arms of Ferdinand IV of Bourbon and that of the city of Lecce duplicated on the sides. Above the entablature rises the crowning gable that houses a commemorative inscription. The sculpture of Saint Blaise in bishop's vestments completes the artistic ornamentation of the gate. This gate is 17.3 meters high.