San Giorgio is an ancient, Romanesque architecture style, Roman Catholic church. It was apparently constructed atop a pagan temple; it is one of oldest churches in Campobasso. The entrance portal has carved Romanesque decoration. 

The walls contain spolia from prior structures. The rectangular bell tower stands aside the church. The entrance to the Chapel of St Gregory is from the presbytery, and it has an octagonal dome above. 

The walls were frescoed in the 15th-century, and depict St Augustine and the Saints. In the right aisle of the Nave is the tomb of Delicata Civerra.