Records show that the monastery already existed in 1318. Occupied first by the Clarissa nuns and then by the Franciscan sisters, inside it preserves a fresco painted by Pietro Perugino in 1522, portraying the Madonna delle Grazie between Saints Antonio Abate and Antonio da Padova with two Franciscan nuns at her feet. In the choir is a fresco said to be the work of Eusebio da San Giorgio (1519). Currently a cloistered monastery.