The Uzeda Gate, opened in 1696 within the sixteenth-century city walls, was built as a southern exit from Piazza del Duomo and to connect the former seminary of the Clerics (now Palazzo dei Chierici) to the Archbishop's Palace and the Cathedral.

It was named after the Spanish viceroy, Giovanni Francesco Paceco, Duke of Uzeda, who governed Sicily from 1687 to 1696.